2. Signaling Pathways
  3. GPCR/G Protein
  4. GnRH Receptor

GnRH Receptor

Gonadotropin releasing hormone receptor; GNRHR

GnRH Receptor

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The GnRH receptor (Gonadotropin-releasing hormone receptor, GNRHR) is a member of the rhodopsin-like G protein-coupled receptor (GPCR) family and consists of seven transmembrane helical domains connected via extra- and intra-cellular segments. GnRH receptor is located on the plasma membrane of gonadotrophs, pituitary cells that synthesize the gonadotrophins LH and FSH.

Mammalian type I and II GnRH receptors show differential ligand preference for GnRH-I (also named as LHRHR) and GnRH-II, respectively. All GnRH receptors activate the Gq/11 family of G proteins, which activate phospholipase C-catalyzed production of second messengers that activate protein kinase C (PKC). GnRH receptor activated by GnRH analogues stimulates the synthesis and release of LH and FSH. GnRH receptors can be used for the research of breast and prostate cancer, regulation of fertility, endometriosis and a range of other medical and veterinary uses.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P0009B
    Cetrorelix diacetate
    		Antagonist
    Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM.
    Cetrorelix diacetate
  • HY-P2082
    [D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH
    		Agonist
    [D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH is a gonadotropin-releasing hormone (Gn-RH) agonist that has a dose-dependent inhibitory activity on progesterone secretion from cultured human granulosa cells.
    [D-pGlu1,D-Phe2,D-NaI3,6]-Gn-RH
  • HY-P3668
    [D-Lys6]-LH-RH
    		Agonist
    [D-Lys6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Lys6]-LH-RH acts as a GnRH receptor agonist.
    [D-Lys6]-LH-RH
  • HY-P3317
    Azaline
    		Antagonist
    Azaline (Azaline A) is a gonadotropin-releasing hormone (GnRH) receptor antagonist with a KD value of 0.48 nM. Azaline can effectively induce histamine release, with an effect comparable to that of GnRH, and it can completely inhibit ovulation at a dose of 2.0-3.0 μg per female rat. Azaline has potential applications in regulating reproductive functions.
    Azaline
  • HY-P5762A
    Phoenixin-14 TFA
    Phoenixin-14 (PNX-14) TFA, a neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH.
    Phoenixin-14 TFA
  • HY-P3673
    Lamprey LH-RH I
    		Activator
    Lamprey LH-RH I is a gonadotropin-releasing hormone, elevates plasma steroid levels and stimulates ovulation in the lamprey without biological activity in other animal models.
    Lamprey LH-RH I
  • HY-P0053A
    Fertirelin acetate
    		Agonist
    Fertirelin acetate is a GnRH and LH-RH analogue. Fertirelin acetate can be used of the study for reversing cow follicular cysts.
    Fertirelin acetate
  • HY-P4536
    (D-Leu6)-LHRH (1-8)
    (D-Leu6)-LHRH (1-8) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (D-Leu6)-LHRH (1-8)
  • HY-16027
    Acyline
    		Antagonist
    Acyline, a GnRH peptide analogue, is a GnRH antagonist that inhibits gonadotropin and testosterone (T) levels.
    Acyline
  • HY-12096A
    WAY-207024 dihydrochloride
    		Agonist
    WAY-207024 (dihydrochloride) is a potent and orally active GnRH antagonist that reduces leuteinizing hormone (LH) levels in plasma.
    WAY-207024 dihydrochloride
  • HY-P4759
    (D-His2)-Goserelin
    (D-His2)-Goserelin is a derivative of Goserelin, a decapeptide analog of gonadotropin-releasing hormone (GnRH/LHRH).
    (D-His2)-Goserelin
  • HY-125611
    Fluorogestone acetate
    		99.60%
    Fluorogestone acetate is a progesterone compound. Fluorogestone acetate inhibits ovulation and synchronizes the estrous cycle in cattle by inhibiting the release of luteinizing hormone (LH) from the pituitary gland.
    Fluorogestone acetate
  • HY-P4442
    (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH
    (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH
  • HY-P3674
    LH-RH (7-10)
    		Activator
    LH-RH (7-10) is a tetrapeptide, one of major degradation products of luteinising-hormone releasing hormone (LHRH) via pituitary and hypothalamus. LH-RH (7-10) produced in macrophages, type I-like and type II pneumocytes.
    LH-RH (7-10)
  • HY-P4467
    (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
    (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH
  • HY-P3663
    [Lys8] LH-RH
    		Activator
    [Lys8] LH-RH is a analogue of LH-RH. [Lys8] LH-RH stimulates LH and FSH release.
    [Lys8] LH-RH
  • HY-16375
    Ozarelix
    		Antagonist
    Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer.
    Ozarelix
  • HY-P10472
    Azaline B
    		Antagonist
    Azaline B is an antagonist for gonadotropin-releasing hormone (GnRH) with IC50 of 1.37 nM, Azaline B can be used in research of sex hormone-related pathological states, ovulation induction and male contraception.
    Azaline B
  • HY-P4577
    (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
    (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH is an analogue of luteinizing hormone-releasing hormone (LHRH). LHRH plays a central role in the control of reproduction by stimulating the release of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
    (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
  • HY-P4441
    (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH
    (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
    (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH
Cat. No. Product Name / Synonyms Application Reactivity